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Deficiency in NO manufacturing is considered a very important marker of endothelial dysfunction, which performs a critical position in atherogenesis. eNOS localizes in caveolae, certain structural and practical lipid domains from the plasma membrane. Scientific studies emphasize the crucial part of endothelial caveolae within the regulation of eNOS activation. In an experiment on rats, it's been proven that destruction of caveolae leads to a minimize in endothelial NO release (73).

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